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Background
Panitumumab is a fully humanized monoclonal antibody that targets the epidermal growth factor receptor (EGFR). Nowadays this drug is widely used in combination with chemotherapy or as monotherapy for treating patients with RAS wild-type metastatic colorectal cancer (mCRC) expressing EGFR as well as for diseases getting worse by taking fluoropyrimidine, oxaliplatin and irinotecan containing chemotherapy regimens (1). It was approved by the U.S. Food and Drug Administration (FDA) in 2006 and also by the European Medicines Agency (EMA) in 2007 and launched in market as Vectibix. Panitumumab have many clinical trials over the last two decades. Unfortunately, a number of studies conducted in different countries showed that panitumumab was associated with a higher risk of grade 3/4 skin toxicities, hypomagnesemia and some other fatal adverse effects. Comparatively, the most common side effect in patients taking Panitumumab is skin reactions including redness, acne-form dermatitis or rash. 


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  • Posted on : October 15th, 2018
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